Reducing occupational exposure: an evaluation of cleaning methods to decontaminate work surfaces exposed to antineoplastic drugs
Author(s): ,
Christel Roland
PharmD candidate
Apolline Adé
PharmD candidate
Johann-François Ouellette Frève
Nicolas Caron
Canadian Pharmacists Conference ePoster Library. Bussières J. 06/03/17; 174248; 29
Mr. Jean-François Bussières
Mr. Jean-François Bussières
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Rate & Comment (0)

Pharmacists, technicians and nurses have the highest potential exposure risk to antineoplastic drugs in health care facilities. Occupational exposure to these drugs can be reduced by an appropriate cleaning of work surfaces and floors. NIOSH and oncology societies have not determined the optimal combination of cleaning products and devices to be used for cleaning of pharmacy and patient care areas potentially contaminated with hazardous drugs. The objective was to compare the efficacy of cleaning products and devices usually employed in healthcare facilities to eliminate environmental contamination to antineoplastic drugs.

This is an evaluative and comparative study of eight cleaning scenarios involving four cleaning products (sodium hypochlorite, quaternary ammonium, hydrogen peroxide, detergent) and two cleaning devices (disposable and reusable microfiber mops). The study was conducted in three phases: the voluntary contamination of the floor of a non-clinical room with a pre-established quantity of cyclophosphamide (20 000 000 ng), the cleaning of the floor according each scenario, the quantification of cyclophosphamide detected on the floor using wipe samples.

A total of 36 wipe samples were performed. Of the four cleaning products tested in triplicata with two different cleaning devices (n=24 samples), the average rate of efficacy of cleaning strategies was 99,72% ± 0,25%. Average rate of efficacy was not statistically different between both disposable and reusable devices (99,58% ±0,28% vs. 99,86 ±0,28) and between the four cleaning products (e.g. detergent 99,53% ±0,41, quaternary ammonium 99,74% ±0,15, sodium hypochlorite 99,86% ±0,11, hydrogen peroxide 99,75% ±0,15). Despite numerous cleanings of the floor, a residual concentration of cyclophosphamide was still detectable (about pg). Further studies are required to confirm the residual traces or analytical cross contamination

The study showed that the efficacy of cleaning products and devices usually employed in healthcare facilities was comparable.

    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Save Settings